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. 1998 Apr 15;508(Pt 2):379–392. doi: 10.1111/j.1469-7793.1998.379bq.x

Figure 7. Effect of AMP-PNP on the activity of human and murine CFTR Cl− channels.

Figure 7

A, comparison of the effect of AMP-PNP (1 mM) on the activity of two human and three murine CFTR Cl− channels. ATP (0.3 mM) and PKA (75 nM) were continuously present in the intracellular solution; voltage was -50 mV. Each trace is 5 s long. B, effect of AMP-PNP (1 mM) on the Po of human (left ordinate) and murine (right ordinate) CFTR Cl− channels. Note the change in scale. Columns and error bars indicate means +s.e.m. (n = 6) for each condition. AMP-PNP (1 mM) increased the Po of human and murine CFTR Cl− channels to 145 ± 17 and 130 ± 11% of the control values, respectively (n = 6; P < 0.05). Other details as in A.