Figure 1. Forskolin hastened the decay of the glycine-evoked current.

A, in a neurone voltage clamped at 0 mV, rapid application of 100 μM glycine induced an outward current (a). If 50 μM forskolin was applied to the cell, and then glycine (100 μM) and forskolin (50 μM) were rapidly co-applied, the glycine-induced current was more transient, although the peak current was unchanged (b). B and C, summary of results of similar experiments performed on 8 neurones. For each cell, the amplitude of the current produced by glycine plus forskolin was normalized to the current produced by glycine alone. The apparent decay time constant (τ_decay) was obtained by fitting the decline of the glycine current to a single exponential function.