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. 1998 May 15;509(Pt 1):117–128. doi: 10.1111/j.1469-7793.1998.117bo.x

Figure 2. NA effects on Ip are not due to a change in the affinity of Na+-K+ pumps for Str.

Figure 2

A, in 8 cells we used 0.5 mm Str to inhibit Ip and record control pump current (Ip(con)) and pump current in 10 μm NA (Ip(NA)). The ratio Ip(NA)/Ip(con) was 1.14 ± 0.02. B, in 9 cells we used 1.0 mm Str to inhibit Ip and record control pump current (Ip(con)) and pump current in 10 μm NA (Ip(NA)). The ratio Ip(NA)/Ip(con) was 1.14 ± 0.04. Thus, the Str-measured stimulation of Ip by NA does not depend on the concentration of Str used to block Ip. This suggests the stimulation is not through an effect of NA on the affinity of the Na+-K+ pump for Str.