Figure 2. Potentiating effect of anticholinesterase agents.

A, single channel currents were recorded by cell-attached patch clamp in 1-day-old Xenopus myocytes. The myocyte was hyperpolarized +60 mV from rest. Note that the open probability caused by ACh release from the myocyte was enhanced by anticholinesterase agents. Data are presented as means ± s.e.m (n). *P < 0.05 compared with control (Student's t test). B, the continuous trace depicts the spontaneous synaptic currents recorded from an innervated muscle cell (holding potential, -60 mV, filtered at 150 Hz). Samples of synaptic currents were superimposed and shown below at higher time resolution.