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Incubation with 300 μM H2O2 for 6-16 min markedly decreased force (•), while tetanic [Ca2+]i (▴) was not significantly affected during submaximal tetani (n= 4). DTT (0.5-1 mM for 6-10 min) applied immediately following the exposure to H2O2 almost restored force to the initial control value, whereas [Ca2+]i remained virtually unaffected.
