Table 1.
Effect of three hyaluronidases on hydraulic conductance of synovial lining, dQs/dPj, below yield pressure and at higher pressures
| Below yield pressure | Above yield pressure | |||
|---|---|---|---|---|
| Control | After enzyme | Control | After enzyme | |
| Streptomyces hyaluronidase | ||||
| Mean of slopes* | 0.90 ± 0.20 (5) | 4.52 ± 0.70 (6) | 2.30 ± 0.13 (6) | 10.72 ± 1.14 (7) |
| Pooled regression† | 0.78 ± 0.22 (23) | 3.43 ± 0.56 (25) | 2.17 ± 0.27 (26) | 10.23 ± 0.80 (32) |
| Leech hyaluronidase | ||||
| Mean of slopes* | 1.29 (1) | 4.79 (2) | 3.14 (1) | 16.84 (2) |
| Pooled regression† | 1.29 ± 0.07 (4) | 5.10 ± 0.60 (7) | 3.14 ± 0.26 (5) | 16.15 ± 1.57 (11) |
| Testicular hyaluronidase | ||||
| Mean of slopes* | 0.54 ± 0.24 (4) | 4.14 ± 1.06 (7) | 2.28 ± 0.14 (5) | 13.84 ± 1.69 (7) |
| Pooled regression† | 0.53 ± 0.13 (21) | 3.82 ± 0.55 (31) | 2.06 ± 0.39 (22) | 13.06 ± 1.64 (27) |
Values are means ± S.E.M. in μl min−1 cmH2O−1.
*
Mean of slopes fitted by regression analysis to each individual pressure-flow plot; values in parentheses, number of animals.
†
Regression slope fitted to a pooled plot of all pressure-flow values; values in parentheses, total number of pooled points.