Figure 1.

Proteins and lipids are covalently modified in the absence of ATM. (A) Mean ratio of nitrotyrosine to tyrosine in whole brain from 3-month-old wild-type (wt) animals (gray bar, n = 5 animals) and Atm-deficient (Atm−/−) animals (black bar, n = four animals). (B) Mean level of F₂-isoprostanes from brain, testes, and thymus in wild-type (gray bars) and age-matched Atm-deficient mice (black bars). ∗, Significance with P < 0.048; ∗∗, significance with P < 0.01. Error bars represent ±SEM. Statistical analyses were performed with Fisher’s exact test.