Figure 2. Indomethacin, but not nitroarginine, inhibits the slow component of the ACh-induced hyperpolarization in the guinea-pig coronary artery.
ACh (10−6 M) was applied for 1 min before (A; Control) and after application of 5 × 10−6 M indomethacin for 25 min (B), and indomethacin and 10−5 M nitroarginine together for 20 min (C), or before (D; Control) and after application of 10−5 M nitroarginine for 5 min (E) and nitroarginine and 5 × 10−6 M indomethacin together for 11 min (F). Traces shown in A-C and D-F were recorded from different single cells.