Table 2.

Estimated quantal parameters at the climbing fibre synapse

Method	Quantal size (nS)	Number of release sites	Number of cells
[Ca2+]/[Mg2+] change at 0.2 Hz
Simple binomial model	0.50 ± 0.04	510 ± 70	6
Simple multinomial model	0.44 ± 0.03	580 ± 80	6
Compound multinomial model	0.50 ± 0.03	510 ± 50	6
(corrected for synaptic conductance)†	(0.50 ± 0.04)
[Ca2+]/[Mg2+] change at 3 Hz
Compound multinomial model*	0.50 ± 0.04	810 ± 220‡	6
Frequency change (0.033–10 Hz)
Compound multinomial model	0.76 ± 0.1	420 ± 50	5
(corrected for synaptic conductance)†	(0.63 ± 0.07)
Frequency change in CNQX
Compound multinomial model (0.033–5 Hz)*	0.100 ± 0.004	480 ± 170	5
Direct measurement
Sr2+	0.55 ± 0.01	—	4
Cd2+	0.64 ± 0.09	—	5

^†q_m corrected for positive correlation between q_m and G (recorded at 0.2 Hz), value expected for G of 200 nS.

^*Compound multinomial model with α constrained to control value as only part of P¯_r range present or too few points to estimate α accurately.

^‡Poorly constrained as estimated from the linear, low P¯_r region of the relationship.