Table 1.
Estimates for sodium current gating parameters at 20–22 °C
| Mutation | Activation, G(V) | Fast inactivation, h∞(V) | Slow inactivation, S∞(V) | ||||
|---|---|---|---|---|---|---|---|
| V½ (mV) | k (mV/e-fold) | V½ (mV) | k (mV/e-fold) | V½ (mV) | k (mV/e-fold) | Io | |
| WT | −25.7 ± 1.4 (12) | 6.3 ± 0.3 | −66.7 ± 0.8 (15) | 4.9 ± 0.2 | −63.3 ± 2.4 (5) | 13.8 ± 0.7 | 0.050 ± 0.002 |
| S804F | −26.2 ± 1.6 (8) | 6.3 ± 0.5 | −63.8 ± 1.2 (9)* | 4.6 ± 0.2 | −66.4 ± 2.5 (5) | 13.5 ± 0.3 | 0.058 ± 0.020 |
| V1293I | −31.5 ± 1.6 (9)* | 6.0 ± 0.3 | −65.2 ± 0.6 (11) | 4.3 ± 0.2 | −65.2 ± 1.4 (7) | 10.7 ± 0.7* | 0.078 ± 0.011 |
Values are means ±s.e.m., with number of experiments in parentheses.
*
Significant difference compared with WT (P < 0.05).