Table 1.
Outline of procedures performed on the eyes of the four monkeys
| Animal no. | Gas bubble, −2 weeks | Subret injected at day 0: material; GC × 1012; μ1 | Expression of EGFP, onset in weeks | Histology | Subret injected at 7 months: AAV; GC × 1012; μ1 |
|---|---|---|---|---|---|
| 94B-102 | |||||
| Eye 1 | ND | rAAV; 50; 50 | 11 | 6 months | ND |
| Eye 2 | ND | Vehicle; 0; 50 | − | 6 months | ND |
| 95C-273 | |||||
| Eye 1 | + | rAAV; 25; 50 | 18 | 11 months | ND |
| Eye 2 | + | Vehicle; 0; 50 | − | 11 months | 3.84; 80 |
| 94B-051 | |||||
| Eye 1 | ND | rAAV; 4.8; 100 | 12 | 11 months | ND |
| Eye 2 | ND | Vehicle; 0; 100 | − | 11 months | 4.3; 90 |
| 94B-109 | |||||
| Eye 1 | + | rAAV; 3.84; 80 | 8 | ND | ND |
| Eye 2 | + | ND; 0; 0 | − | ND | ND |
AAV dose is presented as number of GCs. −, absent; ND, not done.