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. 1998 Sep 1;511(Pt 2):433–450. doi: 10.1111/j.1469-7793.1998.433bh.x

Figure 11. Acid/base disturbances induced small and inconsistent changes in resting whole-cell conductance.

Figure 11

A, stimulated neurone with a CI of 212%. Acidosis induced a decrease in the outward holding current. Recording was made in voltage clamp at a holding potential of −50 mV (resting potential, −57 mV). There was a consistent decrease in outward holding current with hypercapnic acidosis, although the maximum change was only 10 pA. B, whole-cell conductance of the same neurone as in A, measured from a holding potential of −50 mV, with voltage steps to −60 mV. Recording was simultaneous with that in A. Hypercapnic acidosis induced a small decrease in whole-cell conductance to an average of 92% of control. C, inhibited neurone. Alkalosis had no effect on holding current in this inhibited neurone (same neurone as in Fig. 5B). Holding potential, −60 mV (resting potential, −50 mV). D, resting whole-cell conductance of the same neurone as in C, measured from −60 to −70 mV. Recording was simultaneous with that in C. There was no change in whole-cell conductance with hypocapnic alkalosis.