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. 1998 Oct 15;512(Pt 2):421–434. doi: 10.1111/j.1469-7793.1998.421be.x

Figure 5. Effects of iberiotoxin (IbTx) and tetraethylammonium (TEA) on anoxia-sensitive currents in neonatal AMC.

Figure 5

A, in normoxic conditions, IbTx (100 nm) suppressed outward current at +30 mV (left traces); upper trace is control record before IbTx. In the presence of IbTx, anoxia still suppressed outward current reversibly, though washout of the effects of IbTx was incomplete (not shown). B, mean current density (± s.e.m.) vs. voltage plots for 4 cells, in the presence of IbTx. Symbols are same as in Fig. 1. Anoxia significantly suppressed outward current at all voltage steps between 0 and +50 mV (P < 0.05). C, effects of TEA on outward currents. Addition of TEA (20 mm) suppressed ∼96% of outward current (left traces; upper dotted trace is control current for step to +30 mV). Anoxia had no additional effect on outward current in the presence of TEA (middle traces; only steps to +30 and +50 mV shown). D, mean current density vs. voltage plots for a group of 6 cells with similar initial densities; TEA was present throughout. Vertical and horizontal scale bars represent 200 pA and 20 ms, respectively, for both A and C.