Table 1.

Effect of different concentrations of amiloride and 10⁻⁵ m benzamil on responses to 10⁻⁴ m dopamine

			Rate of production of lung liquid (ml (kg body wt)−1 h−1)			Sig. of reductions during treatment		Sig. of reductions aafter treatment
Dopamine m	Na+ channel blockers m	n	Hour before treatment	Hour during treatment	Hour after treatment	ANOVA	Regression analysis	ANOVA	Regression analysis
10−4	0	6	1.27 ± 0.09	−0.27 ± 0.15	0.28 ± 0.32	P < 0.0005	P < 0.0005	P < 0.005	P < 0.0005
Untreated controls		6	1.17 ± 0.23	1.14 ± 0.30	1.02 ± 0.14	n.s.	n.s.	n.s.	n.s.
10−4	10−6 amiloride	12	1.17 ± 0.09	−0.24 ± 0.07	0.27 ± 0.12	P < 0.0005	P < 0.0005	P < 0.005	P < 0.0005
0	10−6 amiloride	6	1.48 ± 0.26	1.23 ± 0.16	1.18 ± 0.21	n.s.	n.s.	n.s.	n.s.
10−4	10−5 amiloride	3	1.14 ± 0.24	−0.39 ± 0.09	−0.39 ± 0.18	P < 0.025	P < 0.0005	P < 0.025	P < 0.0005
0	10−4 amiloride	3	0.97 ± 0.17	0.98 ± 0.12	0.70 ± 0.17	n.s.	n.s.	n.s.	n.s.
10−4	10−4 amiloride	3	0.90 ± 0.21	−0.50 ± 0.11	−0.09 ± 0.03	P < 0.005	P < 0.0005	P < 0.01	P < 0.0005
0	10−4 amiloride	3	1.40 ± 0.12	1.44 ± 0.46	1.18 ± 0.36	n. s.	n.s.	n.s.	n.s.
10−4	10−5 benzamil	6	1.17 ± 0.15	−0.22 ± 0.16	−0.08 ± 0.14	P < 0.0005	P < 0.0005	P < 0.0005	P < 0.0005
0	10−5 benzamil	6	1.06 ± 0.22	1.03 ± 0.11	1.07 ± 0.15	n.s.	n.s.	n.s.	n.s.

All values are means ±s.e.m. Sig., significance.