Figure 4.

Summary of results indicating that kainate receptors mediate the depression of monosynaptic inhibition. The depression was abolished by 50 μM DNQX (A) and reversibly reduced by 2.5–10 mM kynurenic acid (B) or 10 μM Gd³⁺ (C). The depression was nonsignificantly reduced by 100 μM CGP35348 (D) but in the same neurons was abolished by the subsequent addition of DNQX. Blockade of metabotropic receptors with 250 μM MCPG and 200 μM MSOP increased the depression (E). PDC (100–200 μM) had no significant effect on the depression (F). The distal tetanus was 5 pulses at 100 Hz except for the experiments in D, where it consisted of 10 pulses at 200 Hz.