Fig. 3.
Pharmacological inhibitors block RSV activation of MAPK pathways. A549 cells were mock treated (vehicle) or treated with p38 inhibitor (SB-203580; A), JNK inhibitor (SP-600125; B), or ERK inhibitor (U-0126; C) before infection with RSV at MOI of 2.5 pfu/cell. Cellular proteins were separated on 10% SDS-PAGE and blotted using antibodies to the phosphorylated (P) form of the MAPKs followed by visualization using the ECL method. As a control, the blots were stripped and reprobed with specific antibodies to the nonphosphorylated MAPKs (n = 2).