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. Author manuscript; available in PMC: 2008 Feb 5.
Published in final edited form as: Expert Opin Drug Metab Toxicol. 2006 Jun;2(3):381–397. doi: 10.1517/17425255.2.3.381

Figure 1. Ligands for PXR.

Figure 1

Chemical structures of ligands for PXR including pregnane and androstane steroid hormones, bile salts (including an ‘early’ bile salt typical of the earliest bile salts to evolve in vertebrates), the experimental cholesterol-lowering drug SR12813, and the putative endogenous benzoate ligand of the Xenopus laevis BXRα. Note that some of the PXR activators are also agonists of VDR or CAR or, in the case of 5α-androstanol, inverse agonists of human and mouse CAR.