Figure 2.

Fundus photographs and histological cross-sections of optic nerves from eyes with normal IOP and chronic, moderately elevated IOP, with and without treating the animals with aminoguanidine for 6 months. Color fundus photographs (A–C) and red-free photographs for relief imaging (D–F) were taken on anesthetized animals. The highlights in B and C are reflections of light from the camera. Optic nerve cross-sections (G–I) were stained for myelin profiles (magnification, ×1,250). The peripheral edge of the optic nerve is to the right side of each photomicrograph, opposite the label (G–I). Arrows in H point to the approximate boundary between normal-appearing optic nerve tissue and degenerated (deg) tissue. Pictures from the same eyes are as follows: A, D, and G are from an eye with normal IOP and contralateral to B, E, and H, which are from an eye with chronic, moderately elevated IOP for 6 months from an animal not pharmacologically treated. C, F, and I are from an eye with chronic, moderately elevated IOP for 6 months from an animal treated with aminoguanidine.