. Author manuscript; available in PMC: 2008 Feb 6.

Published in final edited form as: Curr Drug Metab. 2006 May;7(4):349–365. doi: 10.2174/138920006776873526

Table 2.

Transcriptional Targets of NR1I Subfamily Members

Human gene	NR1I member(s) upregulating expression in humans and/or rodents	Function	References
CYP2B6	VDR, PXR, CAR	Metabolizing enzyme – endogenous function not well understood	[44, 206–208]
CYP2C9	VDR, PXR, CAR	Metabolizing enzyme – endogenous function not well understood	[206, 209]
CYP3A4	VDR, PXR, CAR	Broad specificity enzyme (steroid hormones, bile salts, xenobiotics) – major adult liver xenobiotic- metabolizing enzyme	[23, 31, 65, 128, 206, 208, 210–212]
CYP3A7	PXR, CAR	Broad specificity enzyme (steroids, bile salts, xenobiotics) – major fetal liver xenobiotic- metabolizing enzyme	[213, 214]
UGT1A1	PXR, CAR	Conjugating enzyme (bile acids, thyroxine, xenobiotics)	[188, 189, 208, 215, 216]
MDR1 (P-glycoprotein, ABCB1)	PXR, CAR	Broad specificity pump	[208, 212, 217, 218]
MRP2 (ABCC2)	PXR, CAR	Broad specificity pump	[208, 219]
CYP24 (25- Hydroxyvitamin 24-D₃- hydroxylase)	PXR, VDR	Inactivation of 25- hydroxyvitamin D₃	[220, 221]
5-aminolevulinic acid synthase-1	PXR, CAR	Rate-limiting enzyme in heme synthesis	[222, 223]
Cytosolic sulfotransferase	CAR	Bile salt detoxification	[126]