Table 1.
cGMP | cAMP | DAG | Tetracaine | ||||
---|---|---|---|---|---|---|---|
Channel | K1/2 | K1/2 | Efficacy | IC50 | Maximal percentinhibition | IC50 | Percentinhibition |
Brod | 31.0 | 1830 | 0.05 | 0.83 | 100 | 2.6 | 94.1 |
Rolf | 2.1 | 37 | 1 | 3.24 | 31 | 139.6 | 10.4 |
Molf | 1.2 | 37 | 1 | 3.50 | 17 | – | 18.8 |
Molf G204E | 1.9 | 37 | 1 | 0.99 | 100 | 10.8 | 78.3 |
Rolf G204E | 1.8 | 37 | 1 | 0.73 | 100 | – | 76.4 |
Rolf G204W | 14.0 | 440 | 0.44 | 0.26 | 100 | 2.2 | 100 |