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. Author manuscript; available in PMC: 2008 Feb 6.
Published in final edited form as: Pharmacoeconomics. 2006;24(11):1101–1119. doi: 10.2165/00019053-200624110-00007

Figure 3. ‘Pooling’ and ‘splitting’ versus hierarchical modelling for multinational trials: estimating country-specific mean difference in cost.

Figure 3

Note: The black circle indicates the trial-wide estimate. The square markers indicate the country-level mean estimates of differential costs. The size of the markers is proportional to the sample of patients recruited in each country. Finally, the horizontal bars represent the 95% confidence intervals.