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. 1999 Mar 30;96(7):3507–3512. doi: 10.1073/pnas.96.7.3507

Figure 1.

Figure 1

Ribozyme-mediated trans-splicing. Ribozyme and target RNAs are indicated schematically, with conserved sequences shown explicitly. In the first step, ribozyme and target RNAs base pair to form the P1 and extended antisense helices. Guanosine-mediated transesterification results in cleavage of the target RNA. The distal portion of helix P1 is displaced by sequences from the 3′ exon to form helix P10, which allows the second transesterification to proceed, and results in ligation of the two exons.