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Response of outside-out patches to a pHo 4.0 solution from control and injected oocytes with ASIC2-3 cRNAs. External protons evoke inward currents (downward deflections) only in oocytes injected with ASIC2-3. In none of the ∼40 control oocytes we observed acid-activated channels. The bars above the traces indicate the applied pHo. Membrane potential was −20 mV. The outside solution contained 150 mM NaCl, and the pipet solution contained 150 mM KCl.
