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. 2001 Jun 1;117(6):563–572. doi: 10.1085/jgp.117.6.563

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Modes of activity of ASIC2-3 channels. The figure shows a continuous record of a single channel activated by pH_o 4.0. The channel exhibits sudden changes in kinetics, which are indicated by bars labeled mode 1, mode 2, mode 3, and mode 4. Holding potential was −80 mV. External and internal solutions contained 150 mM NaCl and 150 KCl, respectively. Closed and open levels are indicated on the right. Current amplitude and time scales are indicated by the bars at the bottom of the record.