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. 2001 Jun 1;117(6):563–572. doi: 10.1085/jgp.117.6.563

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Fast and sustain components of ASIC2-3 currents. (A) Whole-cell currents elicited by changing the pH_o from 7.4 to 4.0 in an oocyte expressing ASIC2-3. The initial current (fast component) partially inactivates and it is followed by a sustain component. Holding potential −60 mV; bath solution contains 100 mN Na⁺. (B) Outside-out patches showing the activation of channels immediately after changing the external solution from pH_o 7.4 to 4.0. Initially, two channel levels are apparent, but after 2.5 s, one of the channels closes. Holding potential −40 mV; outside solution contains 150 mM Na⁺, and pipet solution contains 150 K⁺. (C) All-points amplitude histogram from patches showed in B. The distributions were fitted by the sum of three Gaussian components (continuous lines). The mean amplitudes of the open states were −1.3 ± 0.2 pA and −2.6 ± 0.3 for one and two open levels, respectively.