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. 2001 Jun 1;117(6):563–572. doi: 10.1085/jgp.117.6.563

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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External proton dose–response curve. Open probability of ASIC2-3 was plotted for each increment of [H⁺]_o. Fit of the data to the Hill equation is shown the in solid line. The calculated values were as follows: EC₅₀ = 16 μM, Hill coefficient = 2.7, and maximum P_o = 0.8. Symbols represent the mean P_o obtained from at least 10,000 open and closed events. For some of the points, two to three patches activated by the same pH_o were combined to have sufficient number of events for the analysis.