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. 2000 Jun 1;115(6):749–758. doi: 10.1085/jgp.115.6.749

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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The H16 peptide has no effect on deactivation rate in channels with intact amino termini, indicating that the peptide acts by the same mechanism as the native amino terminus. (A) Tail currents from S620T channels evoked at −140 mV after a voltage step to 60 mV, before and after a 5-min incubation in 1 mM H16 peptide. (Arrow) Initial tail current amplitude. (B) Time constants of dominant fast components of the deactivation extracted from exponential fits to the tail currents were 137.6 ± 16.5 ms, A _f = 90.0 ± 2.3% for the controls, and 167.7 ± 21.5 ms, A _f = 87.6 ± 4.7% after application of the peptide (n = 3). There is no significant difference when tested with ANOVA. (P > 0.3 at confidence level of 0.05.)