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. 2000 Jun 1;115(6):749–758. doi: 10.1085/jgp.115.6.749

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Single-channel activities at negative (repolarizing) potentials display longer open times when the amino terminus is present. During a continuous voltage command of −80 mV, lasting for 3−5 min, single-channel activities were recorded in cell-attached patch with 100 mM potassium in the pipette. Representative segments of the records from S620T and S620TΔ2-354 channels are shown in A and B, with longer openings apparent in S620T channels (n = 3 for each construct). (C and D) Ensemble tail currents and representative single trials of activities from which the ensemble averages were constructed for S620T and S620TΔ2-354 channels, respectively, during a 2-s repolarizing command to −80 mV after depolarization to 60 mV. Deactivation of the ensemble currents displays typical slow phenotype for S620T channel and fast phenotype for S620TΔ2-354 channels (n = 3 for each construct).