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. 2000 Jun 1;115(6):759–768. doi: 10.1085/jgp.115.6.759

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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10 mM caffeine activates a sodium-dependent current in nystatin-perforated patched squid ORNs. (A) Current trace from a nystatin-perforated patched ORN during a 1-s application of 10 mM caffeine. Solutions ASW external (ext)/TMA Cl internal (int). (B) In the same cell, replacing external Na⁺ with Tris⁺ completely eliminated the caffeine-induced current. Solutions: Tris ASW ext/TMA Cl int. (C) A caffeine-activated current response in ASW from a different cell. Same solutions as in A. (D) Current trace from the cell in C in Li⁺ ASW. (E) Average current density of caffeine-induced current responses from squid ORNs in ASW, Tris⁺ ASW, ASW, and Li⁺ ASW, respectively. The holding potential has been corrected for liquid junction potential and is indicated in each panel. Error bars indicate SD. *P < 0.05.