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. 2000 Jun 1;115(6):759–768. doi: 10.1085/jgp.115.6.759

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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DCB reversibly eliminates Na⁺/Ca²⁺ exchange in squid ORNs. (A) 10 mM caffeine elicits a large Na⁺/Ca²⁺ exchange current. (B) After 12 s in the presence of 100 μM DCB, I_NCX is partially blocked and, after 42 s, I_NCX is completely eliminated. (C) After removing DCB and allowing the cell to recover for 2 min, I_NCX is restored. (D) In all 18 cells tested, DCB eliminated I_NCX. Solutions: ASW ext./Na gluconate int. *P < 0.001.