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. Author manuscript; available in PMC: 2008 Feb 6.
Published in final edited form as: J Cereb Blood Flow Metab. 2006 May 10;27(1):123–134. doi: 10.1038/sj.jcbfm.9600330

Figure 2.

Figure 2

Blood–brain barrier integrity is diminished by gp120. R5 gp120 (from the M-tropic HIV-1 strain Bal) (A) and X4 gp120 (from the T-tropic HIV-1 strain MN) (B) decrease blood–brain barrier tightness, and gp120 withdrawal restores it. Negative controls consist of untreated cells (control) and cells treated with heat-inactivated gp120 (heat-gp120). Endothelial cells exposed to 50 mmol/L ethanol (EtOH) served as positive controls. Each experimental condition was performed in triplicate and for each time-point, three independent TEER (Ωcm2) measurements were recorded. The results are expressed as mean percent of controls at initial time point±s.e.m. (n = 3) (*P < 0.05, **P < 0.01, ***P < 0.001). This figure is representative of four independent experiments.