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. 2001 May 1;117(5):457–468. doi: 10.1085/jgp.117.5.457

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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PMA produces a large increase in conductance in a mutant hCFTR (H667R-hCFTR) with an engineered PKC consensus phosphorylation sequence that includes Thr⁶⁶⁵. (A) Representative I-V plot from an oocyte expressing H667R-hCFTR. (B) Summary of results from experiments such as those in A. Oocytes were primed with 25 μM 8-Br-cAMP. Data were obtained from six experiments. The results indicate that the engineered PKC consensus site is sufficient to confer a large response to PKC stimulation.