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. 2001 May 1;117(5):457–468. doi: 10.1085/jgp.117.5.457

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Thr⁶⁶⁵ is critical for activation of XCFTR by PKC-mediated phosphorylation. (A) Representative I-V plot from an oocyte expressing a single knockout of the unique PKC consensus phosphorylation site containing Ser⁶⁹⁴ (S694A-XCFTR). (B) I-V plot from an oocyte expressing a single knockout of the unique PKC consensus phosphorylation site containing Thr⁶⁶⁵ (Thr665/A-XCFTR). (C) Summary of results from experiments identical to those in A (n = 6) and B (n = 14). The results denote a critical role of Thr⁶⁶⁵ in the stimulation of XCFTR by PMA. See Fig. 1 and Fig. 2 for additional details.