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. 2001 May 1;117(5):457–468. doi: 10.1085/jgp.117.5.457

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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The mutation Thr⁶⁶⁵ to Ala does not increase cAMP-activated XCFTR currents. Time course of the currents after stimulation with the cAMP cocktail in oocytes injected with wild-type XCFTR, S686A/S790A-XCFTR, or T665A/S694A-XCFTR cRNAs. Currents were measured at 30 mV, 20 min after exposure to the cAMP cocktail. The data show that the Thr⁶⁶⁵ to Ala mutation has no significant effect on the level of cAMP-activated currents.