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. 2008 Feb 8;4(2):e23. doi: 10.1371/journal.pgen.0040023

Figure 4. Rapidly Evolving Pathways in I. loihiensis .

Figure 4

Simplified schematic of glycolysis and phenylalanine metabolism in I. loihiensis. Metabolic intermediates are denoted by white circles; enzymes by arrows. “Fast-evolving” enzymes, depicted as red arrows, are defined as those with ν in the top 10% of genes in the I. loihiensis genome. The names of genes encoding fast-evolving enzymes are shown, highlighted in light blue or orange, respectively for glycolysis or phenylalanine metabolism. Nonfunctional pathways (those with many key enzymes or transporters missing) are shown in gray. Of the “present” enzymes shown in black, only one is slow-evolving (ν < 1) in Idiomarina: COG 191, encoding the enzyme fructose bisphosphate aldolase, which interconverts F1,6P and GA3P. Abbreviations for metabolic intermediates: PEP, phoshphenolpyruvate; E4P, erythrose-4-phosphate; DAHP, 7P-2-dehydro-3-deoxy-arabinoheptonate; DHQ, 3-dehydroquinate; DHS, 3-dehydroshikimate; prCat, protocatechuate; shik, shikimate; shik-3P, shikimate-3-phosphate; CVPS, 5-O-(1-carboxyvinyl)-3-phosphoshikimate; chor, chorismate; prePh, prephenate; phPy, phenylpyruvate; Phe, phenylalanine; G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; F1,6P, fructose-1,6-bisphosphate; GA3P, glyceraldehyde-3-phosphate; DHAP, dihydroxyacetone phosphate; G1,3P, glyerate-1,3-bisphospate; G3P, glycerate-3-phosphate; G2P, glycerate-2-phosphate. COG and EC numbers of fast-evolving genes: AroB: COG337, EC4.2.3.4; AroQ: COG757, EC4.2.1.10; AroE: COG169, EC1.1.1.25; PheA: COG77, EC4.2.1.51; Pgi: COG166, EC5.3.1.9; Fbp: COG158, EC3.1.3.11; Pfk: COG205, EC2.7.1.11; TpiA: COG149, EC5.3.1.1; Eno: COG148, EC4.2.1.11.