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. 2008 Feb 8;4(2):e30. doi: 10.1371/journal.pgen.0040030

Figure 1. PGC Precursors Show a Pronounced H3K27me3 Nuclear Accumulation Indicative of One Inactive X Chromosome.

Figure 1

XX Blimp1:gfp mouse embryos were immunostained for H3K27me3. GFP under the control of the Blimp1 promoter was tagged to the cell membrane.

(A) E6.5 whole embryo showing in the white box the Blimp1(GFP)-positive PGC progenitors.

(B) Magnification of the Blimp1(GFP)-positive PGC progenitor cluster depicted in (A). White arrows indicate individual H3K27me3-positive nuclear accumulation in the PGC progenitors. Note that all somatic cells exhibit a H3K27me3 nuclear accumulation.

(C) E6.75 and (D) E7.0 whole embryos similarly stained.