Table 2.

Rate Constants of RyR Models Used for Simulation of Channel Activity

Rate constant	Model 1Ca	Model 2Ca	Model 3Ca	Model 4Ca	Model 5Ca	Unit
k on	1.0 × 103	9.2 × 102	8.2 × 102	7.1 × 102	7.1 × 102	μM−1· s−1
k off	1.0 × 105	1.4 × 104	5.5 × 103	3.0 × 103	2.0 × 103	s−1
k Cn O1			1.0 × 104			s−1
k Cn O2			1.0 × 100			s−1
k O1 Cn			5.0 × 102			s−1
k O2 Cn			5.0 × 10−1			s−1
k O1 Cn+1			2.0 × 100			s−1
k Cn+1 O1			6.7 × 10−1			s−1
k O2 Cn+1			3.0 × 103			s−1
k Cn+1 O2			1.0 × 102			s−1
k Cn+1 I			5.0 × 10−1			s−1
k I Cn+1			1.5 × 100			s−1