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. 2000 Sep 1;116(3):363–378. doi: 10.1085/jgp.116.3.363

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Dendrogram showing the three major families of Na-phosphate cotransporters identified in mammalian cells. The multiple sequence alignment was carried out using ClustalX on the derived amino acid sequences for the indicated isoforms (protein weight matrix used was Dayhoff PAM 250; gap penalty, 10; and floating gap penalty, 10; see Thompson et al. 1994). The dendrogram was constructed from the dendrogram output file of ClustalX. The commonly used designation for the given isoform is given in parentheses next to the species type from which the cDNA was isolated. The corresponding gene names for these isoforms as designated by the Human Gene Nomenclature Committee (HGNC) are as follows: (a) SLC17A1 for NaPi-10; (b) SLC20A1 for hPiT1; (c) SLCS20A2 for hPiT2; and (d) SLC34A1 for NaPi-3. There is no name designated by HGNC for hBNP-1.