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. 2000 Sep 1;116(3):449–462. doi: 10.1085/jgp.116.3.449

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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HMM analysis of individual activation episodes for wild-type and εA411P AChRs. (Top) Filtered at 100 kHz bandwidth (see materials and methods); (bottom) the same record filtered at 10 kHz bandwidth; (middle) the most likely current pulse sequences determined by HMM. For εA411P, a particularly low open probability cluster is illustrated.