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. 2000 Sep 1;116(3):449–462. doi: 10.1085/jgp.116.3.449

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Abrupt kinetic switches occur within individual AChR activation episodes. Each trace is an individual activation episode from either wild-type or εA411P AChR. The graphs below plot open probability for groups of 10 openings plus 10 closings across the activation episode. The lower graphs plot the relative window mean (RWM) computed for consecutive 10-event windows across the activation episode (Milone et al. 1998): RWM = {log[(τopen_window1 × τclosed_window2)/τopen_window2 × τclosed_window1]}². The peak in the RWM plot reveals the time of the mode switch (vertical dashed lines).