Table 2.

Effect of Increasing the Number of Autoregression Coefficients in HMM Fitting

	n*	k+	k−	β	α
Simultation rates		2000	17000	100000	4500
HMM fit	2	2400	20000	51200	2300
HMM fit	3	2300	18500	57600	2700
HMM fit	4	2270	18700	63400	3020
HMM fit	5	2250	18200	66200	3200
HMM fit	6	2200	18100	67800	3300
HMM fit, wild-type AChR	4	2170	17040	68400	3200
HMM fit, εA411P AChR	4	1980	19540	64140	4040

The top row gives the Fig. 1 rate constants used to simulate data (see ), in units of s⁻¹. All other rate constants are mean values from HMM fitting. For wild-type and εA411P AChRs, the fitted rate constants are mean values from one patch of membrane. *Number of autoregression coefficients.