Table 2.
n* | k+ | k− | β | α | |
---|---|---|---|---|---|
Simultation rates | 2000 | 17000 | 100000 | 4500 | |
HMM fit | 2 | 2400 | 20000 | 51200 | 2300 |
HMM fit | 3 | 2300 | 18500 | 57600 | 2700 |
HMM fit | 4 | 2270 | 18700 | 63400 | 3020 |
HMM fit | 5 | 2250 | 18200 | 66200 | 3200 |
HMM fit | 6 | 2200 | 18100 | 67800 | 3300 |
HMM fit, wild-type AChR | 4 | 2170 | 17040 | 68400 | 3200 |
HMM fit, εA411P AChR | 4 | 1980 | 19540 | 64140 | 4040 |
The top row gives the Fig. 1 rate constants used to simulate data (see ), in units of s−1. All other rate constants are mean values from HMM fitting. For wild-type and εA411P AChRs, the fitted rate constants are mean values from one patch of membrane. *Number of autoregression coefficients.