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. 2000 Sep 1;116(3):311–326. doi: 10.1085/jgp.116.3.311

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Single-channel voltage and concentration dependence of E340N mutant. (A) Current recordings from a membrane patch containing one E340N channel activated by 3 or 100 μM cGMP at −80 or +80 mV. The continuous lines indicate the closed channel level and the dotted lines indicate two conductance open levels. Amplitude histograms at +80 mV for 3 μM (B) or 100 μM (C) cGMP were fitted as the sum of three Gaussians and shown enlarged in the insets. Histograms were fitted with the following parameters. For 3 μM cGMP: P _closed = 0.765, P _o,low = 0.22, i_low = 1.1 pA, P _o,high = 0.015, i_high = 2.5 pA; for 100 μM cGMP: P _closed = 0.01, P _o,low = 0.925, i_low = 1 pA, P _o,high = 0.065, i_high = 2.5 pA.