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. 2000 Sep 1;116(3):311–326. doi: 10.1085/jgp.116.3.311

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Single-channel dose–response relations for wild-type, E340D, E340N, and E340G channels. Continuous curves show fits of to the dose–response relations using the following parameters. Wild-type: L _cG = 334, K _d,cG = 29 μM, n _cG = 2.3, L _cA = 70, K _d,cA = 333 μM, n _cA = 2.9; E340D: L _cG = 66, K _d,cG = 31 μM, n _cG = 2.6, L _cA = 12, K _d,cA = 558 μM, n _cA = 3; E340G: L _cG = 4.6, K _d,cG = 24 μM, n _cG = 2.4, L _cA = 0.9, K _d,cA = 472 μM, n _cA = 2.3; E340N: L _cG = 10, K _d,cG = 24 μM, n _cG = 3.5, L _cA = 3, K _d,cA = 400 μM, n _cA = 3.5.