Table 1.

Catalytic rate constants for the on and off states of class I (induction) and class II (inhibition) ribozymes compared to constructs designed to simulate these states

Allosteric ribozyme	kobs (×10−1 min−1)		Simulant construct	kobs (×10−1 min−1)
	On	Off		On	Off
Class I (induction)	0.46	0.0017	I-1	0.46	—
			I-2	—	0.21
			I-3	—	0.04
Class II (inhibition)	2.0	0.0080	II-1	0.47	—
			II-2	—	0.0020