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. 2001 Oct 1;118(4):355–376. doi: 10.1085/jgp.118.4.355

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Extracellular application of dantrolene depresses calcium transients in intact mouse skeletal muscle fibers. (A) Effect of dantrolene (25 μM) on the indo-1 calcium transient elicited by a depolarization of 20 ms to 0 mV applied every 30 s. (B) Time-dependent evolution of the peak change in [Ca²+]_i elicited by a 20-ms depolarization to 0 mV upon dantrolene application and after washout. Data points correspond to the mean value obtained from four fibers. For each fiber, data points were normalized to the peak value measured in response to the first depolarization. Here, and in subsequent figures, open circles (○), closed circles (•), and open triangles (Δ) denote measurement taken before, during, and after the extracellular application of dantrolene, respectively.