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. 2001 Oct 1;118(4):355–376. doi: 10.1085/jgp.118.4.355

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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The effects of 5 μM dantrolene on SR calcium permeability. Traces were calculated from the calcium transients presented in Fig. 3 as detailed in materials and methods. Note that dantrolene suppressed both the early peak and the maintained steady level at each and every membrane potential (V_m) tested. The parameters of the removal model were k_off,M-P = 8.2 s⁻¹, PV_max = 2.24 mMs⁻¹, k_on,Ca-E = 1.4 μM⁻¹s⁻¹, and k_off,Ca-E = 1.7 s⁻¹. The estimated SR content for this fiber was 2.5 mM.