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. 2001 Oct 1;118(4):355–376. doi: 10.1085/jgp.118.4.355

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Dantrolene-injected fibers are still susceptible to extracellular dantrolene application. Results shown in A–D were obtained from two distinct fibers that had been injected with dantrolene. (A) Indo-1 calcium transients were elicited by 20-ms-long depolarizations to 0 mV in control (a), and 2 min (b) and 6 min (c) after a brief extracellular application of 25 μM dantrolene. (B) Time-dependent evolution of the peak change in [Ca²+]_i before and after the application of dantrolene. (C) Indo-1 calcium transients elicited by a 30-ms duration pulse to 0 mV in control (a), and upon extracellular application of 0.5 (b), 12 (c), and 25 μM (d) dantrolene. (D) Corresponding time-dependent evolution of the peak change in [Ca²+]_i during the course of the experiment.