Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2003 Oct;122(4):459–469. doi: 10.1085/jgp.200308818

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2003, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 8. — State-dependent modification of KAT1 cysteine mutants currents induced by external MTSET. (A) Voltage protocol for the assay of closed channels. The time course of channel modification was followed by recording every 6 s the ionic current responses to 300 ms or 1 s −160-mV pulses maintaining a constant holding potential during the intervals. Holding potential was 0 mV. (B) For the open-closed protocol the holding potential was −140 mV and the test pulse as in A. MTSET was superfused continuously in the assay of extracellular accessibility during cut-open oocyte voltage clamping. (C) MTSET modification of the macroscopic currents induced by the G163C mutant using the closed protocol. (D) Macroscopic currents induced by the G163C mutant before and after MTSET using the open/closed protocol.