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. 1997 Aug 1;110(2):165–171. doi: 10.1085/jgp.110.2.165

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(A) Location of mutations that lead to inwardly rectifying channels. They are located in domain 1 (D70), at the carboxy-terminal end of domain 3 (K165), in domain 11 (H472, S475) and between domain 11 and domain 12 (E482, T484). (B) Alignment of homologous ClC proteins in the region of the domains D11/D12. hClC-1 is the human muscular chloride channel (Steinmeyer et al., 1991; Koch et al., 1992), ClC-2 is a ubiquitous swelling-activated Cl⁻ channel from rat (Thiemann et al., 1992), ClC-5 is predominantly expressed in kidney (Steinmeyer et al., 1995; Lloyd et al., 1996), ClC-7 is a rather broadly expressed CLC-protein (Brandt and Jentsch, 1995), and scClC is the S. cerevisiae CLC protein GEF-1 (Greene et al., 1993). The prefix r in front of ClC means rat, h means human, and sc means yeast.