Table I.
Amino acid | Full EF-hand database* | Classical EF-hand motif‡ | Kretsinger consensus§ | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Asp | 596 | 55.5% | 482 | 73.3% | 417 | 80.3% | ||||||
Asn | 182 | 17.0% | 161 | 24.5% | 102 | 19.7% | ||||||
Glu | 96 | 8.9% | 2 | 0.3% | ||||||||
Gly | 45 | 4.2% | 2 | 0.3% | ||||||||
Thr | 30 | 2.8% | 3 | 0.5% | ||||||||
Ser | 21 | 2.0% | 6 | 0.9% | ||||||||
Met | 19 | 1.8% | ||||||||||
Cys | 16 | 1.5% | ||||||||||
Ala | 14 | 1.3% | ||||||||||
Leu | 11 | 1.0% | ||||||||||
Lys | 10 | 0.9% | 1 | 0.1% | ||||||||
Gln | 9 | 0.8% | ||||||||||
Ile | 7 | 0.6% | ||||||||||
Arg | 6 | 0.6% | 1 | 0.1% | ||||||||
Pro | 5 | 0.5% | ||||||||||
Val | 5 | 0.5% | ||||||||||
Tyr | 1 | 0.1% | ||||||||||
Phe | ||||||||||||
His | ||||||||||||
Trp | ||||||||||||
Total | 1,073 | 658 | 519 |
Database courtesy of Dr. R.H. Kretsinger (Kawasaki and Kretsinger, 1994).
Defined by the previously described consensus algorithim (Prosite algorithm; Falke et al., 1994) except that position 3 is allowed to vary freely.
Defined by the Kretsinger consensus algorithm for functional EF-hands (Linse and Forsen, 1995).